Modulation of the early inflammatory microenvironment in the alkali-burned eye by systemically administered interferon-gamma-treated mesenchymal stromal cells.

Modulation of the early inflammatory microenvironment in the alkali-burned eye by systemically administered interferon-gamma-treated mesenchymal stromal cells.

Model: Alkali burn of the eye

Labelled cells were more than 30 times more abundant in damaged than control eyes, and only interferon-gamma-pretreated cells significantly reduced the percentage of eye-infiltrating cells, with the largest effect on myeloid cells and significant falls in IL-1 alpha, IL-6 and nitric oxide.

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