Pharmacological blockade of the MaxiK channel attenuates experimental acute pancreatitis and associated lung injury in rats.
RatChemical/toxinWistarmaleCompared as pre-treatment and therapeutic administration after induction
Model: Sodium taurocholate induced acute pancreatitis with secondary lung injury
Paxilline attenuated pancreatitis and lung injury with lower inflammatory cytokines and lung myeloperoxidase, and pre-treatment was more effective than therapeutic dosing.
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