A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion.
MouseIschaemia-reperfusionRenalC57BL/6, Nlrp3 knockout and bone marrow chimerasmaleConstitutive genetic deletion present before injury
Model: Renal ischaemia-reperfusion injury with focus on the repair phase
Both leukocyte and renal Nlrp3 were detrimental to renal function, with leukocyte Nlrp3 associated with tubular apoptosis and macrophage influx while renal Nlrp3 impaired wound healing and tubular proliferation.
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