PRECLINICAL PUBLICATION · 2014

Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Bone marrow mesenchymal stem cells pretreated with valproic acid

PMID 24815388 ↗2014Reported benefit

Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury.

RatSpinal cord injuryUnspecifiedSprague-DawleyIntravenous injectionOne week after injury

Model: Acute spinal cord injury

Valproic acid pretreatment increased CXCR4 expression, improved homing of transplanted cells to the injured cord and produced greater functional improvement, which AMD3100 partially inhibited.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.