Effect of prostaglandin E in multiple experimental models. III. Effect on response to septic challenge.
RatBurnUnspecifiedLewisMaleAfter burn injury
Model: Thermal burn with septic (Pseudomonas) challenge
16,16-dimethyl-prostaglandin E2 increased gut translocation of bacteria, had no significant effect on resting metabolic rate, and increased serum acute-phase proteins in rats with non-septic burns. The authors concluded prostaglandin E may have both detrimental and beneficial effects.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.