Acute reduction of microglia does not alter axonal injury in a mouse model of repetitive concussive traumatic brain injury.
MouseTBIClosed-head / concussionCD11b-TK transgenic on C57BL/6 background1 mg/mL (low), 10 mg/mL (intermediate) and 50 mg/mL (high)…Administered after repetitive injury
Model: Repetitive closed-skull concussive traumatic brain injury
Reducing the microglial population by 35 to 56 percent did not change the extent of axonal injury at acute or subacute time points, and longer or higher-dose valganciclovir was toxic in this model.
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