Losartan improved antioxidant defense, renal function and structure of postischemic hypertensive kidney.
RatIschaemia-reperfusionRenalSpontaneously hypertensive rat (SHR)malen = 9 rats in the losartan treated acute renal failure groupIntravenous infusion into the femoral vein10 mg/kg body mass dissolved in 4 mL salineGiven 5 min before ischaemia, during ischaemia and for 175 min after ischaemia
Model: Right nephrectomy with 40 min clamping of the left renal artery followed by 24 h reperfusion, giving ischaemic acute renal failure
Losartan increased creatinine and urea clearance and HDL, reduced plasma lipid peroxidation, increased erythrocyte catalase, reduced cortico-medullary necrosis and tubular dilatation, and downregulated Bax.
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