PRECLINICAL PUBLICATION · 2014

An amino acid mixture mitigates radiation-induced gastrointestinal toxicity.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Mitigating amino acid mixture (MAAM) containing lysine, aspartic acid, glycine, isoleucine, threonine, tyrosine, valine, tryptophan and serine

PMID 24776907 ↗2014Reported benefit

An amino acid mixture mitigates radiation-induced gastrointestinal toxicity.

MouseRadiationNIH SwissMaleGastric gavage

Model: Whole-body 137Cs irradiation at 0, 1, 3, 5 or 7 Gy delivered at 0.9 Gy per minute

MAAM increased electrolyte absorption and reduced paracellular permeability, IL-1 beta and plasma endotoxin, and was associated with greater weight gain and better survival after irradiation.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.