PRECLINICAL PUBLICATION · 2014

Preclinical development of a bridging therapy for radiation casualties: appropriate for high risk personnel.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Progenitor-enriched whole blood or peripheral blood mononuclear cells from donors treated with tocopherol succinate and AMD3100

PMID 24776901 ↗2014Reported benefit

Preclinical development of a bridging therapy for radiation casualties: appropriate for high risk personnel.

MouseRadiationCD2F1MaleIntravenous transfusionAfter irradiation

Model: Acute high-dose whole-body ionising irradiation causing haematopoietic or gastrointestinal acute radiation syndrome

Infusion of whole blood or mononuclear cells from tocopherol succinate and AMD3100-treated donors significantly improved 30-day survival after high-dose irradiation, comparable with cells from granulocyte colony-stimulating factor-treated donors.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.