The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury.
RatSpinal cord injuryCompressionn = 30 rats, six treatment groups of fiveIntravenous infusionNimodipine 0.02 mg/kg or 0.05 mg/kg, with or without dextra…Infusion commenced 1 h after injury
Model: 53 g clip compression injury of the spinal cord at T-1
Injury reduced spinal cord blood flow from 56.84 to 24.55 ml/100 g/min with significant evoked potential changes. Only nimodipine 0.02 mg/kg combined with dextran 40 raised blood flow to 43.69 ml/100 g/min and improved cord and nerve motor evoked potentials and somatosensory evoked potentials; othe…
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