Antimutagenic and radioprotective activities of beta-carotene against the biological effects of iodine-131 radiopharmaceutical in Wistar rats.
RatRadiationWistarOral gavage0.2 ml of 8 mg beta-carotene per ml corn oil per 100 g body…Simultaneous, pre-treatment, post-treatment and continuous treatment schedules
Model: Iodine-131 radiopharmaceutical exposure at 25 microCi per 100 g body weight, at a dose used to treat hyperthyroidism
Beta-carotene significantly reduced iodine-131-induced chromosomal damage in all acute antimutagenic treatments; reductions in subchronic treatments were not statistically significant, attributed to the low baseline rate of chromosomal abnormalities with iodine-131 alone.
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