SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury.

SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury.

Model: Radiation injury causing thrombocytopenia

Intravenous SDF-1 and stabilisation of endogenous SDF-1 acutely increased megakaryocyte-vasculature association and thrombopoiesis without changing megakaryocyte number, and manipulation of SDF-1 gradients improved radiation-induced thrombocytopenia additively with earlier thrombopoietin treatment.

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