Administration of S-methyl-L-thiocitrulline protects against brain injuries after intracerebral hemorrhage.
RatHaemorrhage/shockUnspecifiedSprague-Dawleyn = 27 rats in totalIntraperitoneal3 mg/kg in 0.9% saline3 hours after haemorrhage induction
Model: Autologous blood infusion of 30 or 50 microlitres into the striatum as a model of intracerebral haemorrhage
SMTC given 3 hours after haemorrhage reduced NADPH-diaphorase activity (p < 0.05), gelatinolytic enzyme activation (p < 0.01), loss of laminin (p < 0.01) and occludin (p < 0.05) staining, neuronal death and neurological deficits at 24 hours.
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