Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice.
MouseRadiationC57BL/6JSubcutaneous injection20 mg/kg single dose (BIO 30 mg/kg also tested in vivo)24 h after total-body irradiation
Model: Total-body irradiation (LD50/30 and 7 Gy LD70/30 doses) causing haematopoietic acute radiation syndrome
A single subcutaneous dose of SB216763 given 24 h after total-body irradiation improved haematopoietic recovery, increased KLS and colony-forming cell frequency, improved 30-day survival by 20 to 25 per cent and extended mean survival time from 13 to 22.5 days at 7 Gy.
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