Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury.
RatChemical/toxinSprague-DawleyMale
Model: Glycerol-induced myoglobinuric (rhabdomyolysis) acute kidney injury; LLC-PK1 cells exposed to myoglobin in vitro
Chlormethiazole prevented the rise in renal catalytic iron, reduced oxidative stress, blocked Nrf2 nuclear translocation and haem oxygenase-1 upregulation, and gave functional and histological protection against myoglobinuric acute kidney injury. CYP2E1 inhibition or silencing in tubular epithelial…
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