Ras regulates alveolar macrophage formation of CXC chemokines and neutrophil activation in streptococcal M1 protein-induced lung injury.

Ras regulates alveolar macrophage formation of CXC chemokines and neutrophil activation in streptococcal M1 protein-induced lung injury.

Model: Streptococcus pyogenes M1 protein-induced acute lung injury

Ras inhibition with FTS reduced neutrophil recruitment, oedema formation and tissue damage in the lung, decreased neutrophil Mac-1 expression and abolished M1 protein-provoked CXC chemokine gene expression in alveolar macrophages.

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