Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits.
RatTBIFluid percussionSprague-DawleyMaleIntravenous, tail vein6 mg/kg, prepared at 2.5 mg/ml in DMSO diluted with 0.9 per…30 min before injury, or 15 min or 30 min or 60 min after injury depending on t…
Model: Unilateral moderate lateral fluid percussion injury
MK-886 given before or after injury blocked leukotriene production, reduced brain swelling at 72 h, attenuated blood-brain barrier disruption in hippocampal CA1, preserved long-term potentiation and reduced spatial learning and memory deficits. Efficacy for synaptic protection required dosing withi…
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