PRECLINICAL PUBLICATION · 2014

Small interfering RNA directed against CTMP reduces acute traumatic brain injury in a mouse model by activating Akt.

Mouse / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Small interfering RNA directed against carboxyl-terminal modulator protein (CTMP siRNA)

PMID 24670215 ↗2014Reported benefit

Small interfering RNA directed against CTMP reduces acute traumatic brain injury in a mouse model by activating Akt.

MouseTBIControlled cortical impactC57BL/6After traumatic brain injury

Model: Controlled cortical impact traumatic brain injury

Phospho-Akt rose in the nucleus from 4 h after injury while CTMP also increased from 4 h and remained elevated to 72 h. CTMP siRNA augmented Akt phosphorylation and significantly improved neurological functional recovery up to 28 days after injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.