Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling.
RatSpinal cord injuryContusionSprague-DawleyMaleTreatment started two weeks after injury and continued for two weeks
Model: Contusion spinal cord injury; primary rat astrocyte cultures
Interleukin-6 was expressed by astrocytes and neurons one week after injury and then declined. Torin2 and rapamycin induced astrocyte interleukin-6 secretion in vitro, and treating injured animals from two weeks after injury produced only a modest effect on mechanical hypersensitivity that was limi…
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