MMP-9 inhibitor SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat.
RatTBIFluid percussionSprague-DawleyMalen = n=15 per group, three groupsIntraperitoneal50 mg/kg in 10% dimethyl sulfoxideFirst dose 30 min after injury
Model: Fluid percussion traumatic brain injury
SB-3CT improved motor and spatial learning performance and preserved hippocampal neurons after fluid percussion TBI compared with saline-treated injured rats.
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