Quinic acid derivative KZ-41 exhibits radiomitigating activity in preclinical models of radiation injury.
MouseRadiationC57BL/6FemaleSubcutaneous for the survival study; intraperitoneal for the vascular injury study100 mg/kgApproximately 26 h after total body irradiation in the survival study; 12, 36 a…
Model: Total body irradiation (137Cs) acute radiation syndrome, and combined total body irradiation with dorsal window postcapillary venule injury
KZ-41 increased 30-day survival by approximately 45% relative to vehicle after lethal total body irradiation (P<0.05) and increased clot formation after radiation-induced venule injury (P<0.05), although blood flow was not improved.
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