Intraluminal nonbacterial intestinal components control gut and lung injury after trauma hemorrhagic shock.
RatHaemorrhage/shockControlledSprague-DawleyMaleHigh molecular weight polyethylene glycol by injection into the duodenum; doxantrazole and ketotifen intraperitoneal; pancreatic duct cannulation and exteriorisation at laparotomyHigh molecular weight polyethylene glycol 5% solution at 30…Polyethylene glycol and pancreatic duct exteriorisation performed during the la…
Model: Trauma-haemorrhagic shock: 3 cm midline laparotomy with 15 min bowel evisceration, blood withdrawal at 1 mL/min to mean arterial pressure 30 to 35 mmHg maintained for 90 min, then resuscitation by reinfusion of shed blood; assessment 3 h after resuscitation
Pancreatic duct exteriorisation abrogated trauma-haemorrhagic shock-induced gut barrier loss, villous injury and mucus loss and partially limited mucus oxidation and nitration. Intraduodenal high molecular weight polyethylene glycol prevented increased gut permeability, villous injury, bacterial tr…
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