Beneficial effects of activated macrophages on sulfur mustard-induced cutaneous burns, an in vivo experience.
Guinea pigChemical/toxinHairless guinea pigMaleIntradermal injection into the wound bedSingle treatment at 15 min or 6 h after exposure; repeated treatment at 15 min,…
Model: Sulfur mustard vapour cutaneous chemical burn
A single early injection reduced damaged epidermal cells and vesication at 24 h, and repeated injections significantly reduced wound area and improved barrier function measured by trans-epidermal water loss up to 10 days, with prolonged inflammatory cell influx.
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