Selective ET(A) receptor blockade protects against cisplatin-induced acute renal failure in male rats.
RatChemical/toxinSprague-DawleyMaleBQ-123 intraperitoneal; bosentan oral by gavageBQ-123 1 mg/kg; bosentan 30 mg/kg1 h before and 1 day after cisplatin
Model: Cisplatin-induced acute renal failure (single 6 mg/kg intraperitoneal dose)
BQ-123 ameliorated the structural, functional and biochemical injury caused by cisplatin, mainly through restoration of superoxide dismutase activity along with improvements in nitric oxide, TNF-alpha and caspase-3, indicating that ETA rather than ETB receptors mediate cisplatin nephrotoxicity.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.