Neutrophil-derived JAML inhibits repair of intestinal epithelial injury during acute inflammation.
MouseWoundintraperitonealsJAML 20 microgram in 100 microlitre; Ad5 10 microgram in 1…Administered after colonoscopic biopsy wounding, with healing assessed at 2 and…
Model: Superficial colonic mucosal wounds induced by colonoscopic biopsy in mice; 3% DSS (wt/vol) for 5 days used separately to induce colitis
Intraperitoneal sJAML and Ad5 significantly inhibited colonic mucosal wound healing at 4 days after wounding (33 +/- 4.2% and 24.3 +/- 3.1% closure) compared with Ad11 or PBS (65.2 +/- 2.7% and 66.7 +/- 3.2%). The agents given in vivo are injurious CAR ligands; the candidate therapeutic is the bloc…
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