Use of insulin-like growth factor in the healing of open wounds in diabetic and non-diabetic rats.
RatWoundWistarMalen = 96 rats in six groups of 16, with 4 rats sampled per group…Topical1% and 3% IGF-1 creamStarted on the day of wounding
Model: 0.9 mm circular full-thickness punch skin wound in alloxan-induced diabetic and non-diabetic rats
Topical 1% and 3% IGF-1 cream accelerated macroscopic re-epithelialisation and significantly increased myofibroblast alpha-smooth muscle actin expression, but acute inflammatory parameters including vascular proliferation and leukocyte counts did not differ significantly between groups.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.