Distinct CD11b+-monocyte subsets accelerate endothelial cell recovery after acute and chronic endothelial cell damage.
MouseOtherCD11b-diphtheria toxin receptor mice and ApoE-/- CD11b-DTR mice; wild type donor cellsTransfusionAfter endothelial injury, with assessment at 7 days
Model: Acute carotid endothelial injury in monocyte-depleted CD11b-DTR mice and chronic hypercholesterolaemia-induced endothelial injury in ApoE-/- CD11b-DTR mice
CD11b+ monocytes improved endothelium-dependent vasoreactivity 7 days after acute injury and homed to the injury site, whereas CD11b-negative cells had no effect. In chronic hypercholesterolaemic injury, interferon-gamma stimulated monocytes decreased endothelial function while interleukin-4 stimul…
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