Albumin fusion prolongs the antioxidant and anti-inflammatory activities of thioredoxin in mice with acetaminophen-induced hepatitis.
MouseChemical/toxinC57BL/6MaleSystemic administrationSystemic administration after acetaminophen; one experiment gave treatment 4 h…
Model: Acetaminophen (paracetamol) overdose-induced hepatitis, including a lethal dose survival model
HSA-Trx significantly improved survival after a lethal acetaminophen dose compared with saline and reduced plasma transaminases more than human serum albumin or thioredoxin alone. It reduced histopathological injury, apoptosis-positive hepatocytes, oxidative stress and inflammatory mediators, and u…
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