Toll-like receptor 4 plays a central role in cardiac dysfunction during trauma hemorrhage shock.
MouseHaemorrhage/shockControlledC57BL/10ScCr (TLR4-deficient) and C57BL/10ScSn (wild type)Malen = TLR4-deficient trauma-haemorrhage n = 7 per group; wild typ…0.3, 1.0, 3.0, 5.0 and 10.0 mg/kg body weight, given as a s…Single bolus at the initiation of haemorrhage
Model: Trauma-haemorrhage: soft tissue injury (cervical incision and left thoracotomy) with blood withdrawal from the jugular vein at 0.82 mL/10 min/30 g until mean arterial pressure reached 35 plus or minus 5 mmHg, maintained for the first 10 min, with cardiac function recorded to 60 min
Trauma-haemorrhage reduced left ventricular pressure by 35.4% and dP/dtmax by 52.9% in wild type mice but not in TLR4-deficient mice. Eritoran at 1, 3, 5 and 10 mg/kg significantly attenuated cardiac dysfunction, with 3 mg/kg giving the greatest effect; 0.3 mg/kg was not significant. TLR4 deficienc…
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