Aging mesenchymal stem cells fail to protect because of impaired migration and antiinflammatory response.
MouseEndotoxin/LPSC57BL/6FemaleAdoptive transfer, route not stated
Model: Endotoxaemia and acute lung injury in young recipient mice with adoptive transfer of aged versus young bone marrow-derived mesenchymal stem cells; old versus young mice also compared for injury response
Aged bone marrow-derived mesenchymal stem cells lacked the anti-inflammatory protective effect seen with young cells after adoptive transfer to endotoxaemic mice, attributed to reduced cytokine and chemokine receptor expression and impaired migration.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.