Protective effects of BML-111 on cerulein-induced acute pancreatitis-associated lung injury via activation of Nrf2/ARE signaling pathway.
MouseChemical/toxinBALB/cMale1 mg/kg1 hour before the first cerulein injection
Model: Severe acute pancreatitis with associated lung injury induced by intraperitoneal cerulein 50 micrograms/kg given seven times at hourly intervals, followed immediately by Escherichia coli lipopolysaccharide 10 mg/kg
BML-111 lowered serum amylase, lung myeloperoxidase and malondialdehyde, wet-to-dry weight ratio and histopathology scores, and raised Nrf2, haem oxygenase-1, NAD(P)H quinone oxidoreductase-1 and superoxide dismutase relative to untreated severe acute pancreatitis.
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