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PRECLINICAL PUBLICATION · 2014

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 24512212 ↗2014Reported benefit

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury.

RatOtherSprague-DawleyMalen = 24 rats divided equally into three groups, n=8 per groupIntraperitoneal10 mg/kg2 hours before the shock wave procedure and at the beginning of the procedure

Model: Right nephrectomy followed by shock wave lithotripsy treatment causing tubular injury in the remaining kidney

1400W reduced renal lipid peroxidation, antioxidant enzyme activity and nitrite and nitrate levels and attenuated the histopathological tubular damage caused by shock wave treatment.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.