Neuroprotective and anti-apoptotic effects of valproic acid on adult rat cerebral cortex through ERK and Akt signaling pathway at acute phase of traumatic brain injury.

Neuroprotective and anti-apoptotic effects of valproic acid on adult rat cerebral cortex through ERK and Akt signaling pathway at acute phase of traumatic brain injury.

Model: Traumatic brain injury in adult rats, acute phase; the specific injury model is not stated in the abstract

Valproic acid given after traumatic brain injury attenuated brain oedema, contusion volume and neuronal apoptosis and partly blocked the rise in caspase-3 activity, with the benefit reduced by ERK or Akt inhibition.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.