Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis.
MouseChemical/toxinBALB/c; SGLT-1 knockout on a C57BL/6 background; nude SKH-1 for the tumour studyFemalen = n=7 per group in the mucositis models, with n=14 split betw…Oral gavage in 100 microlitres of saline25 micrograms/kg, with 0.25 and 2.5 micrograms/kg also test…Administered at the same time as each chemotherapy injection
Model: Chemotherapy-induced gastrointestinal mucositis: single intraperitoneal doxorubicin 20 mg/kg, or intraperitoneal doxorubicin 7 mg/kg plus 5-fluorouracil 100 ng/kg once weekly for three weeks
BLF501 at 25 micrograms/kg preserved crypt proliferation (3.3 +/- 0.5 per cent versus 1.3 +/- 0.2 per cent at 48 hours), limited villus height loss (-12.31 +/- 1.58 per cent versus -36.15 +/- 2.56 per cent) and restored ZO-1, beta-catenin, caspase-3 and ERM expression; it had no effect in SGLT-1 kn…
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