Sphaeralcic acid and tomentin, anti-inflammatory compounds produced in cell suspension cultures of Sphaeralcea angustifolia.
MouseChemical/toxinICRMaleLocal application to the ear in the phorbol ester model; the route for the 45 mg/kg dose is not stated45 mg/kg in the carrageenan footpad model; 225 mM per ear f…
Model: Acute inflammation models: lambda-carrageenan-induced footpad oedema and phorbol ester-induced auricular oedema
At 45 mg/kg tomentin inhibited carrageenan footpad oedema by 58 per cent and sphaeralcic acid by 66 per cent; locally applied tomentin at 225 mM per ear and sphaeralcic acid at 174 mM per ear inhibited phorbol ester auricular oedema by 57 and 86 per cent respectively.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.