The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury.
MouseOtherC57BL/6 background, Abcc6-/- and Abcc6+/- miceHydrodynamic tail vein injection
Model: Cardiac infarction by non-ischaemic cryoinjury and by coronary artery ligation
Delivery of human ABCC6 to approximately 13% of mouse hepatocytes significantly reduced the calcification response to cardiac cryoinjury; Abcc6+/- mice with approximately 38% of wild-type ABCC6 expression showed no calcium deposits after injury.
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