Timing matters: NSAIDs interfere with the late proliferation stage of a repaired rotator cuff tendon healing in rats.
RatOtherWistarMalen = 39 rats, 13 per groupIntraperitoneal injectionGroup A dosed daily for the first 10 postoperative days; group B dosed from pos…
Model: Acute rotator cuff tear created surgically and immediately repaired
Meloxicam given between days 11 and 20 after repair lowered mean maximal load at 3 weeks versus saline controls (P=0.02) and versus early dosing (P=0.05), with lower stiffness than group A (P=0.05); histology showed no apparent differences in cellularity, vascularity, healing or collagen orientation
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