Targeted delivery to cartilage is critical for in vivo efficacy of insulin-like growth factor 1 in a rat model of osteoarthritis.
RatOtherLewisMaleIntra-articular injection into the knee joint
Model: Surgically induced osteoarthritis of the knee following acute articular injury
Fusion with a heparin-binding domain extended retention in articular and meniscal cartilage from under 1 day to 8 days, sustained functional stimulation of meniscal cartilage to at least 4 days (unmodified IGF-1 had no effect at 2 days), and significantly slowed cartilage damage, which unmodified I…
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