Intravenous transplantation of mesenchymal stromal cells to enhance peripheral nerve regeneration.
RatCrushPeripheral-nerve crushSprague-Dawleyn = 18 rats for intravenous injection; 6 sham (vehicle) controlsIntravenous, via the femoral veinDirectly after lesion induction
Model: Sciatic nerve lesion at the level of the piriformis tendon (described as complete section by standardised nerve crush), with preoperative splenectomy
Labelled mesenchymal stromal cells were found within the regenerated sciatic nerve at 21 days. The cell-treated group showed a better sciatic functional index than fibroblast and vehicle controls at 7, 14 and 21 days, with the improvement appearing early.
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