Acute inactivation of the contralesional hemisphere for longer durations improves recovery after cortical injury.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyContinuous intracerebral infusion into the contralesional hemisphereInitiated within hours of the cortical lesion
Model: Focal cortical lesion induced by endothelin-1 microinjection
Increasing the duration of contralesional inactivation accelerated recovery of paretic forelimb grasping. Both 14-day groups performed better than spontaneously recovering animals. Plateau performance correlated with inactivation duration but not with non-paretic forelimb use or performance.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.