Skin derived precursor Schwann cells improve behavioral recovery for acute and delayed nerve repair.
RatOtherLewis (inbred)Male and femalen = 90 rats in the pre-clinical trial; follow-up at 4, 8, 17 an…Injection into the graft or distal to the repair siteAt acute repair, and at delayed repair 11 weeks after transection
Model: Sciatic nerve injury with acellular graft repair, and tibial nerve transection with acute or delayed (11 week) direct repair
SKP-SC treatment gave significantly better ladder-rung performance than all other groups after graft repair, improvement from 5 weeks after acute repair, and significant improvement from 7 weeks after delayed repair. Axon counts were higher and myelin debris lower at 4 and 8 weeks, with improved co…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.