Systemic oxygen delivery by peritoneal perfusion of oxygen microbubbles.
RatOtherWistarMalen = 10 male Wistar rats, 5 per group; one control excluded for…Intraperitoneal perfusion through a 12-gauge indwelling catheter, warmed to 40.4 degrees CTotal infused volume 107 +/- 9 mL of 70 vol% oxygen microfo…Bolus started immediately before pleural perforation and continued thereafter
Model: Right pneumothorax by scalpel perforation of the pleura, producing acute lung trauma with refractory hypoxaemia
Peritoneal oxygen microbubble perfusion gave 100% survival to the 2 hour endpoint, versus median survival of 18.5 minutes for oxygenated saline and 15.5 minutes for untreated controls (log-rank P = 0.002). Oxygen saturation and heart rate stayed within normal ranges for 2 hours in treated rats. Int…
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