Axoplasmic reticulum Ca(2+) release causes secondary degeneration of spinal axons.
MouseSpinal cord injuryUnspecifiedC57BL/6, including transgenic reporter lines and a gain-of-function ryanodine receptor 2 mutant line
Model: Two-photon laser-induced injury of myelinated spinal white matter axons, imaged live
Reducing calcium release from ryanodine and inositol triphosphate receptor mediated axonal stores significantly decreased axonal dieback and bystander injury, whereas a gain-of-function ryanodine receptor 2 mutation or pharmacological promotion of store release worsened both.
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