Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure.
MouseChemical/toxinSW1Male140 mg/kg body weight (low) and 1400 mg/kg body weight (hig…
Model: Carbon tetrachloride intraperitoneally, 1 ml/kg body weight twice weekly for 42 days for chronic liver failure and a single 2 ml/kg dose for acute liver failure
Extract treatment significantly reduced all measured parameters of carbon tetrachloride induced liver injury, including relative liver weight, necrosis, fibrosis, inflammation and serum aspartate transaminase and alanine aminotransferase, in both acute and chronic models.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.