Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity.

Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity.

Model: Cisplatin nephropathy induced by a single administration of cisplatin

HSA-Trx attenuated the cisplatin-induced rise in serum creatinine, blood urea nitrogen and urinary N-acetyl-beta-D-glucosaminidase and the fall in creatinine clearance, substantially reduced tubular injury and apoptosis, suppressed renal oxidative stress markers and lowered TNF-alpha, IL-1 beta and…

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