PRECLINICAL PUBLICATION · 2013

Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury.

Mouse / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Adeno-associated virus serotype 9 vector encoding short hairpin RNA against TRPV1

PMID 24322332 ↗2013Reported benefit

Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury.

MouseOtherFemaleIntrathecal injection into the subarachnoid space at the upper lumbar spine3 weeks after spared nerve injury

Model: Spared nerve injury of the sciatic nerve

Intrathecal AAV9-shTRPV1 effectively suppressed TRPV1 mRNA and protein in the dorsal root ganglia and spinal cord and attenuated nerve injury-induced thermal allodynia from 10 to 28 days after treatment.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.