Blockage of the upregulation of voltage-gated sodium channel nav1.3 improves outcomes after experimental traumatic brain injury.
RatTBIUnspecifiedSprague-DawleyMaleAdministered at 2 h, 4 h, 6 h and 8 h after traumatic brain injury
Model: Experimental traumatic brain injury in rats, with ipsilateral and contralateral hippocampal and cortical assessment
Antisense ODN prevented the elevation of hippocampal Nav1.3 mRNA seen in the aCSF group at 12 h (p<0.01), significantly decreased the number of degenerating neurons in ipsilateral hippocampal CA3 and hilus (p<0.01), reduced ipsilateral hemispheric oedema on MRI T2 imaging at 1, 3 and 7 days (p<0.05…
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