The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome.
MouseEndotoxin/LPSintraperitoneal25 mg/kg12 h after intratracheal LPS, before hyperoxia exposure
Model: Acute respiratory distress syndrome induced by a single intratracheal dose of lipopolysaccharide (0.375 microg/g) followed by exposure to hyperoxia (>95% O2)
Aurothioglucose significantly attenuated LPS plus hyperoxia induced lung injury, increased lung GCLM expression and glutathione levels, and decreased mortality. Glutathione depletion completely prevented the protective effects, indicating the benefit is glutathione dependent.
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