Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury.
MouseRadiationCD2F1malesubcutaneous75-100 mg/kg (75 mg/kg effective)24 h before total-body irradiation
Model: Acute radiation gastrointestinal syndrome after 10-12 Gy 60Co total-body irradiation at 0.6 Gy/min
Delta-tocotrienol at 75 mg/kg significantly enhanced survival across 10 to 12 Gy total-body irradiation, protected intestinal tissue and crypts, reduced apoptotic cells in the jejunum, inhibited gut bacterial translocation, and suppressed radiation-induced IL-1beta, IL-6 and PTK6 expression.
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