Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner.
MouseChemical/toxinC57BL/6, plus ghrelin-deficient and growth hormone secretagogue receptor-deficient micemaleStarted 12 h after bleomycin administration
Model: Bleomycin-induced acute lung injury with subsequent pulmonary fibrosis
Rikkunshito-treated mice showed higher survival, smaller reductions in body weight and food intake, and reduced neutrophil infiltration, vascular permeability, proinflammatory cytokine induction, NF-kappaB activation, alveolar epithelial cell apoptosis and subsequent fibrosis. Protection persisted…
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